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 The leading web portal for pharmacy resources, news, education and careers March 30, 2017
Pharmacy Choice - Pharmaceutical News - Findings from Copenhagen University Hospital Broaden Understanding of Cardiology (The effect of TIcagrelor administered through a nasogastric tube to... - March 30, 2017

Pharmacy News Article

 3/20/17 - Findings from Copenhagen University Hospital Broaden Understanding of Cardiology (The effect of TIcagrelor administered through a nasogastric tube to...

Findings from Copenhagen University Hospital Broaden Understanding of Cardiology (The effect of TIcagrelor administered through a nasogastric tube to COMAtose patients undergoing acute percutaneous coronary intervention: the TICOMA study)

By a News Reporter-Staff News Editor at Cardiovascular Week Data detailed on Cardiology have been presented. According to news originating from Copenhagen, Denmark, by NewsRx correspondents, research stated, "Patients in a coma after cardiac arrest may have adversely affected drug absorption and metabolism. This study, the first of its kind, aimed to investigate the early pharmacokinetic and pharmacodynamic effects of ticagrelor administered through a nasogastric tube (NGT) to patients resuscitated after an out of hospital cardiac arrest (OHCA) and undergoing primary percutaneous coronary intervention (pPCI)."

Our news journalists obtained a quote from the research from Copenhagen University Hospital, "Blood samples were drawn at baseline and at two, four, six, eight, 12, and 24 hours and then daily for up to five days after administration of a 180 mg ticagrelor loading dose (LD), followed by 90 mg twice daily in 44 patients. The primary endpoint was the occurrence of high platelet reactivity (HPR) 12 hours after the LD. Assessment by VerifyNow (VFN) showed 96 (15.25-140.5) platelet reactivity units (PRU), and five (12%) patients exhibited HPR. Multiplate analysis showed 19 (12-29) units (U) at twelve hours, and three patients (7%) had HPR. Ticagrelor and its main metabolite AR-C124910XX concentrations were 85.2 (37.2-178.5) and 18.3 (6.4-52.4) ng/mL. Median times to sufficient platelet inhibition below the HPR limit were 3 (2-6) hours (VFN) and 4 (2-8) hours (Multiplate)."

According to the news editors, the research concluded: "Ticagrelor, administered as crushed tablets through a nasogastric tube, leads to sufficient platelet inhibition after 12 hours, and in many cases earlier, in the vast majority of patients undergoing pPCI and subsequent intensive care management after an OHCA."

For more information on this research see: The effect of TIcagrelor administered through a nasogastric tube to COMAtose patients undergoing acute percutaneous coronary intervention: the TICOMA study. Eurointervention, 2017;12(14):1782-1788 (see also Cardiology).

The news correspondents report that additional information may be obtained from H. Ratcovich, Dept. of Cardiology, Rigshospitalet, Copenhagen, Denmark. Additional authors for this research include G. Sadjadieh, H.B. Andersson, M. Frydland, S. Wiberg, N.P. Dridi, J. Kjaergaard and L. Holmvang.

Keywords for this news article include: Europe, Denmark, Copenhagen, Cardiology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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