Findings from Columbia University Medical Center Provides New Data on Head and Neck Cancer (Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas)
By a News Reporter-Staff News Editor at Clinical Oncology Week Investigators publish new report on Oncology - Head and Neck Cancer. According to news reporting originating from New York City, New York, by NewsRx correspondents, research stated, "The PI3K/AKT/mTOR signaling pathway has emerged as one of the most frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Numerous alterations of various upstream and downstream components have been described; however, their prognostic significance and impact on HNSCC patient survival remains to be established."
Our news editors obtained a quote from the research from Columbia University Medical Center, "This was addressed using an unbiased cohort of 93 consecutive and homogeneous surgically treated HNSCC patients and results confirmed in 432 HNSCC patients. Our findings reveal the high prevalence of S6 phosphorylation, a surrogate marker of mTORC1 activation, in HNSCC specimens (>70%) and, more importantly, demonstrate its relevance on clinical outcome. Phosphorylation of ribosomal protein S6 on either Ser235/236 or Ser240/244 was consistently and significantly correlated with favorable prognosis, although with differences depending on the tumor site. Thus, p-S6 expression was significantly correlated with better disease-specific survival specifically in the subgroup of laryngeal carcinoma patients (p <0.001). In addition, multivariate regression models revealed p-S6 to be an inverse and independent predictor of lymph-node metastasis (p=0.004) and distant metastasis (p=0.006). Taken together, this study unveils an unprecedented correlation of mTOR activation with improved clinical outcome in patients with laryngeal carcinomas and uncovers the potential of p-S6 expression as a good prognostic biomarker and an inverse predictor of lymph node and distant metastases."
According to the news editors, the research concluded: "These results should be of broad interest as immunohistochemical detection of p-S6 may help to stratify patients and guide treatment decisions."
For more information on this research see: Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas. Oncotarget, 2016;7(20):29780-93 (see also Oncology - Head and Neck Cancer).
The news editors report that additional information may be obtained by contacting D. Garcia-Carracedo, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, United States. Additional authors for this research include M.A. Villaronga, S. Alvarez-Teijeiro, F. Hermida-Prado, I. Santamaria, E. Allonca, L. Suarez-Fernandez, M.V. Gonzalez, M. Balbin, A. Astudillo, P. Martinez-Camblor, G.H. Su, J.P. Rodrigo and J.M Garcia-Pedrero.
Keywords for this news article include: Oncology, New York City, United States, Head and Neck Cancer, Squamous Cell Carcinoma, North and Central America.
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