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 The leading web portal for pharmacy resources, news, education and careers August 20, 2017
Pharmacy Choice - Pharmaceutical News - Data on Cardiac Arrhythmias Described by Researchers at Sheba Medical Center (SK4 K channels are therapeutic targets for the treatment of cardiac... - August 20, 2017

Pharmacy News Article

 3/20/17 - Data on Cardiac Arrhythmias Described by Researchers at Sheba Medical Center (SK4 K channels are therapeutic targets for the treatment of cardiac...

Data on Cardiac Arrhythmias Described by Researchers at Sheba Medical Center (SK4 K channels are therapeutic targets for the treatment of cardiac arrhythmias)

By a News Reporter-Staff News Editor at Cardiovascular Week Investigators discuss new findings in Heart Disorders and Diseases - Cardiac Arrhythmias. According to news originating from Tel Hashomer, Israel, by NewsRx correspondents, research stated, "Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a stress-provoked ventricular arrhythmia, which also manifests sinoatrial node (SAN) dysfunction. We recently showed that SK4 calcium-activated potassium channels are important for automaticity of cardiomyocytes derived from human embryonic stem cells."

Financial supporters for this research include Israel Science Foundation, Israel Academy of Sciences and Humanities (see also Heart Disorders and Diseases - Cardiac Arrhythmias).

Our news journalists obtained a quote from the research from Sheba Medical Center, "Here SK4 channels were identified in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from healthy and CPVT2 patients bearing a mutation in calsequestrin 2 (CASQ2-D307H) and in SAN cells from WT and CASQ2-D307H knock-in (KI) mice. TRAM-34, a selective blocker of SK4 channels, prominently reduced delayed afterdepolarizations and arrhythmic Ca transients observed following application of the b-adrenergic agonist isoproterenol in CPVT2-derived hiPSC-CMs and in SAN cells from KI mice. Strikingly, ECG recording showed that intraperitoneal injection of the SK4 channel blockers, TRAM-34 or clotrimazole, greatly reduced the arrhythmic features of CASQ2-D307H KI and CASQ2 knockout mice at rest and following exercise."

According to the news editors, the research concluded: "This work demonstrates the critical role of SK4 Ca-activated K channels in adult pacemaker function, making them promising therapeutic targets for the treatment of cardiac ventricular arrhythmias such as CPVT."

For more information on this research see: SK4 K channels are therapeutic targets for the treatment of cardiac arrhythmias. Embo Molecular Medicine, 2017;():. (Wiley-Blackwell - www.wiley.com/; Embo Molecular Medicine - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1757-4684)

The news correspondents report that additional information may be obtained from M. Arad, Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Tel Aviv, Israel. Additional authors for this research include D. Weisbrod, H. Bueno, D. Yadin, J. Behar, A. Peretz, O. Binah, E. Hochhauser, M. Eldar, Y. Yaniv, M. Arad and B. Attali.

Keywords for this news article include: Asia, Israel, Genetics, Cardiology, Tel Hashomer, Therapeutics, Cardiomyocyte, Cardiac Arrhythmias, Heart Disorders and Diseases.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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