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 The leading web portal for pharmacy resources, news, education and careers April 28, 2017
Pharmacy Choice - Pharmaceutical News - Astex bags milestone after Novartis cancer drug approved [Syrian Arab News Agency] - April 28, 2017

Pharmacy News Article

 3/17/17 - Astex bags milestone after Novartis cancer drug approved [Syrian Arab News Agency]

Astex Pharmaceuticals has pocketed a milestone payment from Novartis after the cancer drug the companies worked on together a decade ago secured FDA approval. The milestone was triggered when FDA signed off on the use of Kisqali as a first-line treatment for HR-positive, HER2-negative advanced breast cancer.

Approval of Kisqali comes 11 years after Novartis struck a $520 million (489 million) deal with Astex to gain the rights to two cell-cycle inhibitors and form a collaboration to discover similar candidates. That led to the publication of a paper on the crystal structure CDK4 by a team mostly made up of people from Astexs site in Cambridge, U.K.

The approval of CDK4/6 inhibitor Kisqali, ne LEE001, is the culmination that work.

We are absolutely delighted that Novartis has received this first approval of a cancer drug arising from our productive collaboration. This milestone further validates the power of our Pyramid platform and the excellence of our science. Its a moment to celebrate when such ground-



(c) International 2006-2017, SANA Provided by SyndiGate Media Inc. (Syndigate.info).

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