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 The leading web portal for pharmacy resources, news, education and careers August 19, 2017
Pharmacy Choice - Pharmaceutical News - Studies Conducted at University of Reading on Drug Delivery Systems Recently Reported (Synthesis and evaluation of mucoadhesive acryloyl-quaternized... - August 19, 2017

Pharmacy News Article

 7/17/17 - Studies Conducted at University of Reading on Drug Delivery Systems Recently Reported (Synthesis and evaluation of mucoadhesive acryloyl-quaternized...

Studies Conducted at University of Reading on Drug Delivery Systems Recently Reported (Synthesis and evaluation of mucoadhesive acryloyl-quaternized PDMAEMA nanogels for ocular drug delivery)

By a News Reporter-Staff News Editor at Nanotechnology Weekly New research on Drugs and Therapies - Drug Delivery Systems is the subject of a report. According to news reporting from Reading, United Kingdom, by VerticalNews journalists, research stated, "Poly((2-dimethylamino)ethyl methacrylate) (PDMAEMA) nanogels were synthesized via surfactant-free free-radical polymerization technique in aqueous conditions utilizing N,N'-methylene-bis-acrylamide (MBA) as a crosslinking agent. The PDMAEMA nanogels were subsequently quaternized with acryloyl chloride in order to yield mucoadhesive materials which incorporate two mucoadhesive concepts; electrostatic interactions and covalent bond forming acrylate groups."

The news correspondents obtained a quote from the research from the University of Reading, "The native PDMAEMA nanogels were found to exhibit good mucoadhesive properties on ex vivo bovine conjunctival tissues, which was found to increase proportionally with the degree of quaternization. With a view to determine the ocular drug delivery capabilities of the materials, both quaternized and native nanogels were loaded with pilocarpine hydrochloride via an absorption method, and their in vitro release profiles were analysed."

According to the news reporters, the research concluded: "The nanogels were found to exhibit a high loading capacity (>20% of total weight) and a sustained release over 6 h."

For more information on this research see: Synthesis and evaluation of mucoadhesive acryloyl-quaternized PDMAEMA nanogels for ocular drug delivery. Colloids and Surfaces B-Biointerfaces, 2017;155():538-543. Colloids and Surfaces B-Biointerfaces can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands.

Our news journalists report that additional information may be obtained by contacting V.V. Khutoryanskiy, University of Reading, Sch Pharm, Reading RG6 6UR, Berks, United Kingdom.

Keywords for this news article include: Reading, United Kingdom, Europe, Drug Delivery Systems, Emerging Technologies, Drugs and Therapies, Nanotechnology, Nanogels, University of Reading.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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