Register Now
Why register?
Login
 The leading web portal for pharmacy resources, news, education and careers June 24, 2017
Pharmacy Choice - Pharmaceutical News - Corvus Pharmaceuticals to Present Data That Advances the Understanding of the Adenosine Pathway in Immuno-Oncology, including New Clinical Data on CPI-444 at AACR 2017 - June 24, 2017

Pharmacy News Article

 3/20/17 - Corvus Pharmaceuticals to Present Data That Advances the Understanding of the Adenosine Pathway in Immuno-Oncology, including New Clinical Data on CPI-444 at AACR 2017

BURLINGAME, Calif., March 20, 2017 (GLOBE NEWSWIRE) Corvus Pharmaceuticals, Inc. (Nasdaq:CRVS), a clinical-stage biopharmaceutical company focused on the development and commercialization of novel immuno-oncology therapies, today announced that it will present interim data from its ongoing Phase 1/1b study of CPI-444 as a single agent and in combination with Genentech's Tecentriq (atezolizumab) in an oral plenary session at the American Association for Cancer Research (AACR) Annual Meeting 2017, which is taking place April 1-5 in Washington, D.C. The Company will also present preclinical and clinical data on CPI-444, as well as preclinical data on its investigational humanized monoclonal anti-CD73 antibody, in poster presentations. In a separate invited oral presentation, CPI-444 will be featured as a novel oral checkpoint inhibitor of adenosine mediated suppression of tumor immunity. The following are details for the six oral and poster presentations. The abstract for the oral plenary session will be available on the AACR website on March 31 at 4:30 p.m. ET.

Oral Presentations

Abstract #: CT119
Title: CPI-444, an oral adenosine A2a receptor (A2AR) antagonist, demonstrates clinical activity in patients with advanced solid tumors
Presenter: Leisha Emens, M.D., Ph.D., associate professor of oncology, John Hopkins Sidney Kimmel Comprehensive Cancer Center
Session Type: Oral Plenary
Presentation Date and Time: Tuesday, April 4, 10:30 a.m.-12:45 p.m. ET
Location: Ballroom C, Level 3, Washington Convention Center

Title: CPI-444 A Novel Oral Checkpoint Inhibitor of Adenosine Mediated Suppression of Tumor Immunity
Presenter: Ian McCaffery, Ph.D., Corvus Pharmaceuticals
Session Type: Invited Oral
Presentation Date and Time: Saturday, April 1, 3:15-5:15 p.m. ET
Location: Ballroom A-B, Level 3, Washington Convention Center

Poster Presentations

Abstract #: 5593/Poster #: 25
Title: Inhibition of A2AR induces anti-tumor immunity alone and in combination with anti-PD-L1 in preclinical and clinical studies
Presenter: Stephen Willingham, Ph.D., Corvus Pharmaceuticals
Presentation Date and Time: Wednesday, April 5, 8:00 a.m-12:00 p.m. ET
Location: Convention Center, Halls A-C, Poster Section 24

Abstract #: 5598/Poster #: 30
Title: Adenosine signaling through A2AR limits the efficacy of anti-CTLA4 and chemotherapy in preclinical models
Presenter: Po Y. Ho, Corvus Pharmaceuticals
Presentation Date and Time: Wednesday, April 5, 8:00 a.m-12:00 p.m. ET
Location: Convention Center, Halls A-C, Poster Section 24

Abstract #: 5579/Poster #: 11
Title: Strategic inhibition of adenosine A2A receptor (A2AR) by CPI-444 improves CD8+:Treg ratios and enhances T-cell killing of a HER-2/neu expressing murine tumor
Presenter: Blake A. Scott, Johns Hopkins University School of Medicine
Presentation Date and Time: Wednesday, April 5, 8:00 a.m-12:00 p.m. ET
Location: Convention Center, Halls A-C, Poster Section 24

Abstract #: 5577/Poster #: 9
Title: A novel CD73-blocking antibody reduces production of immunosuppressive adenosine and restores T-cell function
Presenting Author: Emily Piccione, Ph.D., Corvus Pharmaceuticals
Presentation Date and Time: Wednesday, April 5, 8:00 a.m.-12:00 p.m. ET
Location: Convention Center, Halls A-C, Poster Section 24

About Corvus Pharmaceuticals
Corvus Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the development and commercialization of small molecule and antibody agents that target the immune system to treat patients with cancer. These agents block or modify crucial immune checkpoints and reprogram immune T-cells. Corvus lead product, CPI-444, is a checkpoint inhibitor that is designed to disable a tumor's ability to subvert attack by the immune system by inhibiting adenosine in the tumor microenvironment. CPI-444 is a small molecule that is taken orally. CPI-444 is currently being evaluated in a multicenter Phase 1/1b clinical trial in patients with various solid tumors. This successive expansion cohort trial is examining the activity of CPI-444 both as a single agent and in combination with Genentech's Tecentriq (atezolizumab), an anti-PD-L1 antibody. Corvus is conducting the trial with Genentech, a member of the Roche Group, under a clinical trial collaboration the two companies entered into in October 2015. For more information, visit www.corvuspharma.com.

Tecentriq is a registered trademark of Genentech.

Corvus Contact:
Jason Coloma
SVP, Chief Business Officer 
Corvus Pharmaceuticals, Inc.
+1-650-900-4511
jcoloma@corvuspharma.com

Media Contact:
Julie Normart
Pure Communications
+1-415-946-1087
jnormart@purecommunications.com

Primary Logo

Source: Corvus Pharmaceuticals


2017 GlobeNewswire, Inc.

Pharmacy News Index
  Drug Delivery Systems
  Drugstores
  FDA Final Approvals
  Front Page Healthcare News
  Generic Drugs
  Hospital Industry
  Internet Pharmacy
  IT in Healthcare
  Medicare & Medicaid
  Over-the-Counter Drugs
  Pharm Industry Trends and Policy
  Pharmaceutical Development
  Pharmaceutical Industry

LIVE ONLINE CE

Last Chance
Jun 25: Legal & Practical Issues in Compounding Pharmacy
Jun 26: Drug Diversion & the Law: Considerations for Pharmacists & Technicians
Jun 27: Medication Adherence: To Take or Not to Take…That is the Problem
Jun 28: Mobile Applications for Pharmacists: Tools That Help Pharmacies be Successful
Jun 29: REMS Drugs & The Practice of Pharmacy: A Program in Law and Risk Management
Click for entire Webinar Calendar

Special Announcement

Free Membership
Enjoy Drug Search, industry newsletters and more...

Nursing Jobs
Are you a nurse looking for a job?

Check out the Nursing Job Source.

Your number one choice for nursing jobs.



Websites » RxCareerCenter.comRxSchool.comClubStaffing.comNursingJobSource.comRN.com
Copyright © 2017 Pharmacy Choice - All rights reserved.
Terms and Conditions | Privacy Statement
888-682-4415