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 The leading web portal for pharmacy resources, news, education and careers May 23, 2017
Pharmacy Choice - Pharmaceutical News - Reports Summarize Drug Delivery Systems Study Results from National University of Singapore (Directing Assembly and Disassembly of 2D MoS Nanosheets... - May 23, 2017

Pharmacy News Article

 5/19/17 - Reports Summarize Drug Delivery Systems Study Results from National University of Singapore (Directing Assembly and Disassembly of 2D MoS Nanosheets...

Reports Summarize Drug Delivery Systems Study Results from National University of Singapore (Directing Assembly and Disassembly of 2D MoS Nanosheets with DNA for Drug Delivery)

By a News Reporter-Staff News Editor at Drug Week Fresh data on Drugs and Therapies - Drug Delivery Systems are presented in a new report. According to news reporting originating from Singapore, Singapore, by NewsRx correspondents, research stated, "Layer-by-layer (LbL) self-assembled stacked Testudo-like MoS superstructures carrying cancer drugs are formed from nanosheets controllably assembled with sequence-based DNA oligonucleotides. These superstructures can disassemble autonomously in response to cancer cells' heightened ATP metabolism."

Financial support for this research came from National Research Foundation Singapore (see also Drugs and Therapies - Drug Delivery Systems).

Our news editors obtained a quote from the research from the National University of Singapore, "First, we functionalize MoS nanosheets (MoS-NS) nanostructures with DNA oligonucleotides having thiol-terminated groups (DNA/MoS-NS) via strong binding to sulfur atom defect vacancies on MoS surfaces. The driving force to assemble into a higher-order DNA/MoS-NS superstructure is guided by a linker aptamer that induced interlayer assembly. In the presence of target ATP molecules, these multilayer superstructures disassembled as a consequence of stronger binding of ATP molecules with the linking aptamers. This design plays a dual role of protection and delivery by LbL stacked MoS-NS similar in concept to a Greek Testudo."

According to the news editors, the research concluded: "These superstructures present a protective armor-like shell of MoS-NS, which still remains responsive to small and infiltrating ATP molecules diffusing through the protective MoS-NS, contributing to an enhanced stimuli-responsive drug release system for targeted chemotherapy."

For more information on this research see: Directing Assembly and Disassembly of 2D MoS Nanosheets with DNA for Drug Delivery. Acs Applied Materials & Interfaces, 2017;():. (American Chemical Society - www.acs.org; Acs Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)

The news editors report that additional information may be obtained by contacting B.L. Li, Dept. of Chemical and Biomolecular Engineering, National University of Singapore , Singapore 117585, Singapore. Additional authors for this research include M.I. Setyawati, L. Chen, J. Xie, K. Ariga, C.T. Lim, S. Garaj and D.T Leong.

Keywords for this news article include: Asia, Genetics, Nanosheets, DNA Research, Nanotechnology, Drugs and Therapies, Drug Delivery Systems, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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