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 The leading web portal for pharmacy resources, news, education and careers August 19, 2017
Pharmacy Choice - Pharmaceutical News - Formation of artificial cells with a skeletal support reinforcement to withstand application realized - August 19, 2017

Pharmacy News Article

 7/14/17 - Formation of artificial cells with a skeletal support reinforcement to withstand application realized

By a News Reporter-Staff News Editor at Drug Week Liposomes have been used as a material in many common products such as capsules for drug delivery and cosmetics. However, the membrane is fragile, leading to problems such as collapse of liposomes by slight stimulus, causing the entrapped compounds to easily leak. To improve the function of liposome as a capsule, it has been needed to develop a method that can toughen liposomes and control their strength (see also Biotechnology - Liposomes).

In order to increase the strength of liposomes, Miho Yanagisawa at Tokyo University of Agriculture and Technology, Masahiro Takinoue at Tokyo Institute of Technology, and their colleagues developed a network structure of DNA that supported membranes similar to a cytoskeleton in living cells using DNA nanotechnology (Figure 1A). The DNA strands used in this study bind to each other and create a network structure by decreasing temperature (Figure 1B). Also, since DNA has negative electric charge, using the attractive force between DNA and the inner layer of liposome with positive charge, they succeeded in forming a DNA cytoskeleton that directly supported the liposome membrane as backing. Liposomes are generally easy to collapse even when a slight osmotic pressure was applied to liposomes. In contrast, liposomes with the DNA cytoskeleton they developed were tolerant of an osmotic pressure even when the applied osmotic pressure was comparable to that assumed to be applied in our body (Figure 2). This reinforcement function is derived from the network structure of DNA; also, there is an advantage that the strength of the DNA cytoskeleton can be control by the DNA base sequence design. In addition, since the artificial cytoskeleton is formed using DNA, it is expected to impart various functions such as induction of membrane collapse based on DNA chemical reactions for controlled release of entrapped compounds.

This research results are published on the online version of Proceedings of the National Academy of Sciences of the United States of America on June 26, 2017.

Keywords for this news article include: Cytoskeleton, DNA Research, Cellular Structures, Intracellular Space, Cytoplasmic Structures, Biotechnology - Liposomes, Tokyo Institute of Technology.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



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