Data on Transdermal Delivery Reported by Researchers at Shaanxi University of Chinese Medicine (Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization)
By a News Reporter-Staff News Editor at Biotech Week Data detailed on Drugs and Therapies - Transdermal Delivery have been presented. According to news originating from Xianyang, People's Republic of China, by NewsRx correspondents, research stated, "Nanoemulsions have been widely applied to dermal and transdermal drug delivery. However, whether and to what depth the integral nanoemulsions can permeate into the skin is not fully understood."
Our news journalists obtained a quote from the research from the Shaanxi University of Chinese Medicine, "In this study, an environment-responsive dye, P4, was loaded into nanoemulsions to track the transdermal translocation of the nanocarriers, while coumarin-6 was embedded to represent the cargoes. Particle size has great effects on the transdermal transportation of nanoemulsions. Integral nanoemulsions with particle size of 80 nm can diffuse into but not penetrate the viable epidermis. Instead, these nanoemulsions can efficiently fill the whole hair follicle canals and reach as deep as 588 mm underneath the dermal surfaces. The cargos are released from the nanoemulsions and diffuse into the surrounding dermal tissues. On the contrary, big nanoemulsions, with mean particle size of 500 nm, cannot penetrate the stratum corneum and can only migrate along the hair follicle canals. Nanoemulsions with median size, e.g. 200 nm, show moderate transdermal permeation effects among the three-size nanoemulsions. In addition, colocalization between nanoemulsions and immunofluorescence labeled antigen-presenting cells was observed in the epidermis and the hair follicles, implying possible capture of nanoemulsions by these cells."
According to the news editors, the research concluded: "Nanoemulsions are advantageous for transdermal delivery and potential in transcutaneous immunization."
For more information on this research see: Size-dependent penetration of nanoemulsions into epidermis and hair follicles: implications for transdermal delivery and immunization. Oncotarget, 2017;(): (see also Drugs and Therapies - Transdermal Delivery).
The news correspondents report that additional information may be obtained from R. Su, Shaanxi University of Chinese Medicine, Xianyang, People's Republic of China. Additional authors for this research include W. Fan, Q. Yu, X. Dong, J. Qi, Q. Zhu, W. Zhao, W. Wu, Z. Chen, Y. Li and Y. Lu.
Keywords for this news article include: Asia, Biotechnology, Xianyang, Nanoemulsion, Nanotechnology, Drugs and Therapies, Transdermal Delivery, Emerging Technologies, People's Republic of China.
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