Studies from Federal University Yield New Information about Toxicology and Pharmacology (Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure)
By a News Reporter-Staff News Editor at Drug Week Data detailed on Drugs and Therapies - Toxicology and Pharmacology have been presented. According to news reporting out of Curitiba, Brazil, by NewsRx editors, research stated, "Paracetamol is one of the most widely sold non-prescription drugs. This study aimed to evaluate the effects of the paracetamol on reproductive, biochemical, genetic, histopathological and hematogical biomarkers by water-borne exposure."
Funders for this research include CAPES (Coordination for the Improvement of Higher Education Personnel), CNPq (Brazilian Agency for Science and Technology), INCT-TA/CNPq (see also Drugs and Therapies - Toxicology and Pharmacology).
Our news journalists obtained a quote from the research from Federal University, "Male fish of Rhamdia quelen were exposed to environmental concentrations of paracetamol (0, 0.25, 2.5 mu g/L) in a semi-static bioassay for 21 days. Hemoglobin and hematocrit were reduced upon exposure to 0.25 mu g/L of paracetamol. Leukocytes and thrombocytes increased after paracetamol exposure. Paracetamol reduced testosterone levels in all exposed groups and increased estradiol levels at higher concentration. Serotonin and dopamine levels increased at exposure to 0,25 mu g/L. Paracetamol also caused protein carbonyls and increased SOD activity in fish exposed to 2.5 mu g/L and in addition led to an inhibition of EROD and GST activities in both concentrations. Hepatic genotoxicity occurred at the 0.25 mu g/L concentration. Hepatic tissues of exposed fish showed mild blood congestion and leucocytes infiltration. The results showed that paracetamol disrupted the hypothalamic-pituitary-gonadal axis, changed hematological parameters and caused hepatotoxicity in Rhamdia quelen."
According to the news editors, the research concluded: "The findings suggest that this drug merits attention relative to its potential endocrine disrupter effect and hepatotoxicity, even at concentrations found in the aquatic environment."
For more information on this research see: Paracetamol causes endocrine disruption and hepatotoxicity in male fish Rhamdia quelen after subchronic exposure. Environmental Toxicology and Pharmacology, 2017;53():111-120. Environmental Toxicology and Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Environmental Toxicology and Pharmacology - www.journals.elsevier.com/environmental-toxicology-and-pharmacology/)
Our news journalists report that additional information may be obtained by contacting I.C. Guiloski, Federal University of Parana, Dept. of Pharmacol, BR-81530990 Curitiba, PR, Brazil. Additional authors for this research include J.L.C. Ribas, L.D.S. Piancini, A.C. Dagostim, S.M. Cirio, L.F. Favaro, S.L. Boschen, M.M. Cestari, C. da Cunha and H.C.S. de Assis.
Keywords for this news article include: Curitiba, Brazil, South America, Toxicology and Pharmacology, Drugs and Therapies, Federal University.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC