Studies from Fuzhou University Have Provided New Data on Drug Delivery Systems (Dual-Targeting Multifuntional Mesoporous Silica Nanocarrier for Codelivery of siRNA and Ursolic Acid to Folate Receptor Overexpressing Cancer Cells)
By a News Reporter-Staff News Editor at Biotech Week Researchers detail new data in Drugs and Therapies - Drug Delivery Systems. According to news reporting from Fujian, People's Republic of China, by NewsRx journalists, research stated, "A targeting drug delivery system (TDDS) can selectively deliver antitumor drugs to cancerous parts to improve its anticancer efficacy. Hence, a targeted drug delivery system (UA/siVEGF@MSN-FA) coloading ursolic acid (UA) and vascular endothelial growth factor (VEGF) targeted siRNA (siVEGF) based on mesoporous silica (MSN) nanocarrier modified by a folic acid (FA) molecule was designed and synthesized."
Financial support for this research came from National Natural Science Foundation of China (see also Drugs and Therapies - Drug Delivery Systems).
The news correspondents obtained a quote from the research from Fuzhou University, "The MSN-FA nanoparticles were investigated for shape, diameter, and zeta potential and and by infrared (IR) spectroscopy. FR-overexpressing HeLa cells and FR-negative HepG2 cell lines were used to evaluate the in vitro cellular uptake and the cytotoxicity of MSN-FA nanoparticles. The morphology of HeLa cells transfected with siVEGF@MSN-FA was observed using fluorescence microscopy. Our findings demonstrated that UA@MSN-FA nanoparticles were near-spherical, and the particle size was about 209 +/- 9.21 nm. The MSN-FA nanocarrier not only could enhance the in vitro transfection efficiency and the stability of siVEGF but also could further improve the targeted anticancer efficacy of UA and siVEGF via the active targeting property of FA."
According to the news reporters, the research concluded: "Overall, the MSN-FA drug delivery system could serve as an excellent material in biomedical applications."
For more information on this research see: Dual-Targeting Multifuntional Mesoporous Silica Nanocarrier for Codelivery of siRNA and Ursolic Acid to Folate Receptor Overexpressing Cancer Cells. Journal of Agricultural and Food Chemistry, 2017;65(32):6904-6911. Journal of Agricultural and Food Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Agricultural and Food Chemistry - www.pubs.acs.org/journal/jafcau)
Our news journalists report that additional information may be obtained by contacting J.W. Shao, Fuzhou Univ, Canc Metastasis Alert & Prevent Center, State Key Lab Photocatalysis Energy & Environm, Pharmaceut Photocatalysis, Fuzhou 350116, Fujian, People's Republic of China. Additional authors for this research include Y.L. Shen, R.R. Zhao, F. Chen, Y. Zhang, A.X. Xu and G.R. Zheng.
Keywords for this news article include: Fujian, People's Republic of China, Asia, Small Interference RNAs, Drug Delivery Systems, Emerging Technologies, Drugs and Therapies, Cancer Therapy, Nanotechnology, Biotechnology, Nanoparticle, Oncology, Genetics, siRNA, Fuzhou University.
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