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 The leading web portal for pharmacy resources, news, education and careers November 19, 2017
Pharmacy Choice - Pharmaceutical News - "Crystalline Form of Afatinib Dimaleate" in Patent Application Approval Process (USPTO 20170240533) - November 19, 2017

Pharmacy News Article

 9/14/17 - "Crystalline Form of Afatinib Dimaleate" in Patent Application Approval Process (USPTO 20170240533)

By a News Reporter-Staff News Editor at Politics & Government Week A patent application by the inventors SINGH, Shravan Kumar (Mirzapur, IN); VERMA, Shyam Sunder (Varanasi, IN); SINGH, Kaptan (Gurgaon, IN); PRASAD, Mohan (Gurgaon, IN), filed on October 1, 2015, was made available online on August 31, 2017, according to news reporting originating from Washington, D.C., by VerticalNews correspondents.

This patent application is assigned to Sun Pharmaceutical Industries Limited.

The following quote was obtained by the news editors from the background information supplied by the inventors: "Afatinib dimaleate is a tyrosine kinase inhibitor, chemically designated as 2-butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[(3S)-tetrahydro-3-furanyl]oxy] 6-quinazolinyl]-4-(dimethylamino)-,(2E)-, (2Z)-2-butenedioate (1:2) having the structure depicted by Formula I.


"The discovery of new polymorphic forms of a compound is important in the development of pharmaceuticals, as these new forms may result in improved as ease of handling, ease of processing, storage stability, ease of purification, improved dissolution profile, and/or improved shelf-life.

"U.S. Pat. No. 8,426,586 and PCT Publication Nos. WO 2012/121764 and WO 2013/052157 provide processes for the preparation of crystalline forms of afatinib and its salts."

In addition to the background information obtained for this patent application, VerticalNews journalists also obtained the inventors' summary information for this patent application: "The present invention relates to crystalline Form I of afatinib dimaleate, its preparation and pharmaceutical composition thereof, and its use in the treatment of metastatic non-small cell lung cancer.

"The crystalline Form I of afatinib dimaleate of the present invention is highly pure, free-flowing, has good solubility, and prolonged shelf life. It is also stable towards polymorphic conversion and exhibits good bioavailability."

URL and more information on this patent application, see: SINGH, Shravan Kumar; VERMA, Shyam Sunder; SINGH, Kaptan; PRASAD, Mohan. Crystalline Form of Afatinib Dimaleate. Filed October 1, 2015 and posted August 31, 2017. Patent URL:

Keywords for this news article include: Pharmaceutical Companies, Sun Pharmaceutical Industries Limited, Sun Pharmaceutical Industries Ltd.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC

(c) 2017 NewsRx LLC

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