By a News Reporter-Staff News Editor at Cancer Weekly Investigators publish new report on Drugs and Therapies - Drug Delivery Systems. According to news reporting originating from Shaanxi, People's Republic of China, by NewsRx correspondents, research stated, "Despite the fact that progress has been made in the application of supramolecular prodrug self-assemblies to enhance the functionality of drug-delivery systems, corresponding research on multi-responsive supramolecular prodrug self-assemblies for programmed drug delivery is still limited. In this paper, the synthesis and self-assembly behavior of supramolecular prodrug complexes (SPCs) with beta-cyclodextrin-acylhydrazone-doxorubicin (beta-CD-hydrazone-DOX) and the targeting of azobenzene-terminated poly[2-(dimethylamino)ethyl methacrylate] (Azo-PDMA-FA) as a building block were investigated."
Our news editors obtained a quote from the research from the Shaanxi University of Science and Technology, "The obtained SPCs could also form self-assemblies on the basis of their amphiphilic nature. Next, SPC-based multi-compartment vesicles and complex micelles, which were confirmed by transmission electron microscopy and dynamic/static light scattering, were obtained with good reversibility under alternative visible light or UV irradiation. Furthermore, three-stage programmed drug-delivery behavior was observed from dual-responsive SPC-based self-assemblies by utilizing UV and pH stimuli. Specifically, the SPCs first self-assembled into multicompartmental vesicles, which was accompanied by a slow release of DOX. Next, UV-light irradiation induced the dissociation of beta-CD/Azo, which led to morphology transition and a slight increase in the rate of release of DOX. Upon transferring the self-assemblies to phosphate-buffer solution (pH 5.0), the release rates increased notably as a result of the broken acylhydrazone bond."
According to the news editors, the research concluded: "Finally, basic cell experiments further demonstrated that the SPC-based self-assemblies could be internalized into cancer cells, which suggests their promise for applications in cancer therapy."
For more information on this research see: Photo- and pH- Dual-Responsive beta-Cyclodextrin-Based Supramolecular Prodrug Complex Self-Assemblies for Programmed Drug Delivery. Chemistry-An Asian Journal, 2018;13(24):3903-3911. Chemistry-An Asian Journal can be contacted at: Wiley-V C H Verlag Gmbh, Postfach 101161, 69451 Weinheim, Germany (see also Drugs and Therapies - Drug Delivery Systems).
The news editors report that additional information may be obtained by contacting Y. Bai, Shaanxi Univ Sci & Technol, Shaanxi Key Lab Chem Addit Ind, Xian 710021, Shaanxi, People's Republic of China. Additional authors for this research include C.P. Liu, X. Song, L.H. Zhuo, H.T. Bu and W. Tian.
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