By a News Reporter-Staff News Editor at Cancer Gene Therapy Week Research findings on Biotechnology - Cancer Gene Therapy are discussed in a new report. According to news reporting originating in Gauhati, India, by NewsRx journalists, research stated, "The primary aim of liposomal drug delivery is to wisely modulate the drug delivery system in order to target diseased tissues. Temperature-sensitive liposomes function as a prospective weapon to combat toxic side effects corresponding to direct infusion of anticancer drugs."
The news reporters obtained a quote from the research from the Indian Institute of Technology, "The main objective of the present study is to model liposomal drug release, subsequent drug transport in solid tumour along with integrated actions of tumour cell surface and endosomal events. Generalized mathematical model for liposomal drug delivery is proposed in which vital physical phenomena, such as kinetics of liposome-encapsulated drug, free drug release from liposomes, transport of both liposomal drug and free drug into the tumour compartment, plasma clearance, protein-drug interactions, drug-tumour cell receptor interactions, internalization of drug through endocytosis along with corresponding endosomal events. The model is expressed through a system of coupled partial differential equations along with appropriate set of initial, interface and boundary conditions which is solved numerically. Simulated results are compared with respective existing experimental data to demonstrate the potency and reliability of the proposed model. Graphical representations of time variant concentration profiles are illustrated to understand the underlying phenomena in details. Moreover, the model speaks for the sensitivity of important drug kinetic parameters, such as advection coefficients, drug release coefficient, plasma clearance rate and internalization parameters through graphical portrayals."
According to the news reporters, the research concluded: "The proposed model and the simulated results act as a tool in designing a more effective drug delivery system for cancerous tumours."
For more information on this research see: Mathematical modelling of liposomal drug release to tumour. Mathematical Biosciences, 2018;306():82-96. Mathematical Biosciences can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Mathematical Biosciences - www.journals.elsevier.com/mathematical-biosciences/)
Our news correspondents report that additional information may be obtained by contacting K. Chakravarty, Indian Inst Technol Guwahati, Dept. of Math, Gauhati 781039, India (see also Biotechnology - Cancer Gene Therapy).
The direct object identifier (DOI) for that additional information is: https://doi.org/10.1016/j.mbs.2018.10.012. This DOI is a link to an online electronic document that is either free or for purchase, and can be your direct source for a journal article and its citation.
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