Researchers at Farr Institute of Health Informatics Research Target Electronic Medical Records (White cell count in the normal range and short-term and long-term mortality: international comparisons of electronic health record cohorts in ...)
By a News Reporter-Staff News Editor at Cardiovascular Week A new study on Information Technology - Electronic Medical Records is now available. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Electronic health records offer the opportunity to discover new clinical implications for established blood tests, but international comparisons have been lacking. We tested the association of total white cell count (WBC) with all-cause mortality in England and New Zealand."
Funders for this research include Wellcome Trust, Medical Research Council, National Institute for Health Research, Health Research Council of New Zealand (see also Information Technology - Electronic Medical Records).
Our news editors obtained a quote from the research from the Farr Institute of Health Informatics Research, "Primary care practices in England (ClinicAl research using LInked Bespoke studies and Electronic health Records (CALIBER)) and New Zealand (PREDICT). Analysis of linked electronic health record data sets: CALIBER (primary care, hospitalisation, mortality and acute coronary syndrome registry) and PREDICT (cardiovascular risk assessments in primary care, hospitalisations, mortality, dispensed medication and laboratory results). People aged 30-75 years with no prior cardiovascular disease (CALIBER: N=686 475, 92.0% white; PREDICT: N=194 513, 53.5% European, 14.7% Pacific, 13.4% Maori), followed until death, transfer out of practice (in CALIBER) or study end. HRs for mortality were estimated using Cox models adjusted for age, sex, smoking, diabetes, systolic blood pressure, ethnicity and total:high-density lipoprotein (HDL) cholesterol ratio. We found 'J'-shaped associations between WBC and mortality; the second quintile was associated with lowest risk in both cohorts. High WBC within the reference range (8.65-10.05?10/L) was associated with significantly increased mortality compared to the middle quintile (6.25-7.25?10/L); adjusted HR 1.51 (95% CI 1.43 to 1.59) in CALIBER and 1.33 (95% CI 1.06 to 1.65) in PREDICT. WBC outside the reference range was associated with even greater mortality. The association was stronger over the first 6 months of follow-up, but similar across ethnic groups. Clinically recorded WBC within the range considered 'normal' is associated with mortality in ethnically different populations from two countries, particularly within the first 6 months."
According to the news editors, the research concluded: "Large-scale international comparisons of electronic health record cohorts might yield new insights from widely performed clinical tests."
For more information on this research see: White cell count in the normal range and short-term and long-term mortality: international comparisons of electronic health record cohorts in England and New Zealand. Bmj Open, 2017;7(2):e013100. (BMJ Publishing Group - group.bmj.com/; Bmj Open - bmjopen.bmj.com/)
The news editors report that additional information may be obtained by contacting A.D. Shah, Farr Institute of Health Informatics Research, UCL Institute of Health Informatics, London, UK. Additional authors for this research include S. Thornley, S.C. Chung, S. Denaxas, R. Jackson and H. Hemingway.
Keywords for this news article include: London, Europe, Cardiology, United Kingdom, Cardiovascular, Information Technology, Electronic Medical Records.
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