By a News Reporter-Staff News Editor at Health & Medicine Week A patent application by the inventors RAYBIN, Samuel (Marlborough, MA); CHENG, Ruth (Natick, MA); SMITH, Paul (Smithfield, RI); SUON, Naroun (Lawrence, MA), filed on October 14, 2016, was made available online on May 4, 2017, according to news reporting originating from Washington, D.C., by NewsRx correspondents (see also Biotechnology Companies).
This patent application is assigned to Boston Scientific Scimed, Inc.
The following quote was obtained by the news editors from the background information supplied by the inventors: "Organ walls are composed of several layers: the mucosa (the surface layer), the submucosa, the muscularis (muscle layer), and the serosa (connective tissue layer). In gastrointestinal, colonic, and esophageal cancer, e.g., small polyps or cancerous masses may form along the mucosa and often extend into the lumens of the organs. Conventionally, this condition is treated by cutting out a portion of the affected organ wall. This procedure, however, may cause discomfort to patients, and pose health risks. Recently, physicians have adopted a minimally invasive technique called endoscopic mucosal resection (EMR), and another called endoscopic submucosal dissection (ESD), which removes the cancerous or abnormal tissues (e.g., polyps), keeping the walls intact. EMR may also assist in removing any undesired tissue, even if such tissue is not abnormal or diseased. For purposes of this disclosure, the term 'lesion' or 'abnormality' includes, and will be used to refer to, these cancerous or abnormal tissues generally.
"EMR and ESD are generally performed with an endoscope, which may be a long, narrow elongate member optionally equipped with a light, imaging device, and other instruments and defining a lumen extending from a proximal to a distal end of the elongate member. During ESD, the endoscope is passed down the throat or guided through the rectum to reach an undesired tissue, such as a polyp, in an affected organ. The distal end of the endoscope, typically equipped with a hood carrying dissecting tools such as a small wire loop, a band, or a knife is guided towards the undesired tissue. For EMR, the undesired tissue may be drawn into the hood. This may be achieved by applying suction through working channel extending along the lumen, or by retracting a retraction tool that is extendable from the endoscope. When the undesired tissue is sufficiently drawn into the hood, the dissecting tool may dissect portions of the tissue or resect target tissue from the organ wall. Subsequently, the excised tissue may be extracted for examination, biopsy, or disposal.
"For ESD, the hood is typically used to create a working volume, applying tissue tension for endoscopic instruments, and preventing extraneous tissue and debris from interfering with the operator's visualization and operation.
"Conventional endoscopic hoods may provide sufficient volume to operate on, e.g., small areas of target tissue (.about.smaller than 30 mm), but prove insufficient for dissecting, e.g., larger areas of target tissue (.about.larger than 30 mm). The volume offered by conventional hoods is not sufficient to effectively grasp and resect larger tissue area, such as, e.g., large lesions. As a result, certain large lesions may not be resected properly, forcing the operator to perform the procedure multiple times. Numerous attempts, along with increased operation time, increase the risk of damaging the submucosal wall and causing irreparable damage to the surrounding tissue.
"Therefore, there exists a need for an improved ESD or resection hood that aids in grasping and/or dissecting tissue and resecting small and large areas of target tissue without damaging the surrounding tissue or muscle layers of the organ."
In addition to the background information obtained for this patent application, NewsRx journalists also obtained the inventors' summary information for this patent application: "Embodiments of the present disclosure provide a device for resecting an undesired mass or otherwise unwanted tissue from a patient's body using a minimally invasive surgical method.
"In accordance with an aspect of the present disclosure, a medical device may include an elongate member having a proximal end and a distal end. The distal end of the elongate member further includes a distal portion defining an end face and a cavity extending distally there from. The distal portion further including a plurality of sections configured to transition between a first position and a second position different than the first position. Further, a mechanism may be configured to adjust a volume of the cavity to, e.g., allow for resection of larger tissue volumes, by moving at least one of the plurality of sections from the first position to the second position. In other instances, the embodiments disclosed herein may be used to separate tissue layers along natural intersections. For example, the embodiments of FIGS. 3A-3B may be used for tunneling and separating the muscularis layer from the mucosal layer. The hood may be used as blunt plow-like device, or may be opened to force the layers apart. Further, the embodiments disclosed herein may be used to place tissue under tension to, e.g., assist in cutting the tissue.
"In various embodiments, the device may include one or more of the following features: the distal portion may be removably coupled to elongate member; the plurality of sections may include two sections; the plurality of sections may include four sections; the cavity may include a distally-facing opening; at least one of the plurality of sections may be biased towards the first position; the elongate member may further include a plurality of channels extending between the proximal and distal ends; a tissue cutting device may be disposed in one of the plurality of channels; and at least one of the plurality of sections may include edges configured to cut through tissue. Further, the devices disclosed herein may be shaped (e.g., tapered or pointed) to aid in delivery through tissues or tight spaces. That is, the devices disclosed herein may include a leading nose to assist in delivery.
"In accordance with another aspect of the invention, a medical device may include an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The distal end may define an end face of the elongate member. The medical device further includes a hood having a proximal end and a distal end, such that the proximal end is configured to receive the distal end of the elongate member. Further, a distal portion of the hood includes a plurality of sections configured to transition between a closed state and an open state, the plurality of sections defining a cavity extending distally from the end face of the elongate member.
"In various embodiments, the device may include one or more of the following features: the hood may include a flexible material and the plurality of sections may be formed by slits introduced in the flexible material; the plurality of sections may include four sections; wherein, when the plurality of sections are in the open state, the cavity may include a distally-facing opening; wherein, when the plurality of sections are in the closed state, the cavity does not include a distally-facing opening; and wherein transitioning the plurality of sections from the closed state to the open state increases a dimension of the cavity. Further, the hoods disclosed herein may include a lubricious material, coating, or surface geometry.
"In accordance with yet another aspect of the invention, a medical device may include an elongate member having a proximal end, a distal end, and a lumen extending therebetween. The distal end defines an end face of the elongate member. The medical device further includes a hood including a proximal end and a distal end. A distal portion of the hood includes a plurality of sections configured to transition between a closed state and an open state. The plurality of sections may define a cavity extending distally from the end face of the elongate member. The device may further include a sheath including a proximal end, a distal end, and one or more channels extending therebetween. The sheath may be configured to slidably receive the hood within one of the channels. The hood may be configured to transition between the closed state while in the channel of the sheath and the open state while out of the channel.
"In various embodiments, the device may include one or more of the following features: the plurality of sections may be made integrally with one another; the plurality of sections may be biased towards the open state; and a device configured to sever tissue.
"Additional objects and advantages of the instant disclosure will be set forth in part in the description, which follows, and in part will be obvious from the description, or may be learned by practice of the present disclosure. The objects and advantages of the invention will be realized and attained by means of the elements and combinations particularly pointed out in the appended claims.
"It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed."
URL and more information on this patent application, see: RAYBIN, Samuel; CHENG, Ruth; SMITH, Paul; SUON, Naroun. Expandable Endoscopic Hoods and Related Methods of Use. Filed October 14, 2016 and posted May 4, 2017. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PG01&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.html&r=1&f=G&l=50&s1=%2220170112359%22.PGNR.&OS=DN/20170112359&RS=DN/20170112359
Keywords for this news article include: Risk and Prevention, Biotechnology Companies, Boston Scientific Scimed Inc..
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC