Data on Atrial Fibrillation Reported by Researchers at Princess Margaret Hospital (Atrial fibrillation patients who sustained warfarin-associated intracerebral haemorrhage have poor neurological outcomes: results from a matched case series)
By a News Reporter-Staff News Editor at Drug Week Investigators discuss new findings in Heart Disorders and Diseases - Atrial Fibrillation. According to news reporting originating from Hong Kong, People's Republic of China, by NewsRx correspondents, research stated, "Coagulopathy-associated intracerebral haemorrhage has become increasingly common because of the rising demand in the ageing population for anticoagulation for atrial fibrillation. This study compared the clinical features and neurological outcomes of intracerebral haemorrhage in patients with atrial fibrillation who were prescribed warfarin with those who were not."
Our news editors obtained a quote from the research from Princess Margaret Hospital, "This was a retrospective matched case series of patients with intracerebral haemorrhage from three tertiary hospitals in Hong Kong from 1 January 2006 to 31 December 2011. Patients who developed intracerebral haemorrhage and who were prescribed warfarin for atrial fibrillation (ICH-W group) were compared with those with intracerebral haemorrhage and not prescribed warfarin (ICH-C group); they were matched for age and gender in 1:1 ratio. Clinical features and neurological outcomes were compared, and the impact of coagulopathy on haematoma size was also studied. We identified 114 patients in the ICH-W group with a mean age of 75 years. Both ICH-W and ICH-C groups had a median intracerebral haemorrhage score of 2. There was a non statistically significant trend of higher intracerebral haemorrhage volume in the ICH-W group (12.9 mL vs 10.5 mL). The median modified Rankin Scale and the proportion with good recovery (modified Rankin Scale score <= 3) at 6 months were comparable. Nonetheless, ICH-W patients had higher hospital mortality (51.8% vs 36.0%; P=0.02) and 6-month mortality (60.5% vs 43.0%; P=0.01) than ICH-C patients. Overall, 60% of ICH-W patients had their admission international normalised ratio within the therapeutic range during intracerebral haemorrhage, and 14% had a subtherapeutic admission international normalised ratio. International normalised ratio at admission was not associated with intracerebral haemorrhage volume or neurological outcome."
According to the news editors, the research concluded: "Warfarin-associated intracerebral haemorrhage in patients with atrial fibrillation carried a higher stroke mortality than the non-warfarinised patients."
For more information on this research see: Atrial fibrillation patients who sustained warfarin-associated intracerebral haemorrhage have poor neurological outcomes: results from a matched case series. Hong Kong Medical Journal, 2017;23(2):117-121. Hong Kong Medical Journal can be contacted at: Hong Kong Acad Medicine Press, 9, F, Room 901, 99 Wong Chuk Hang Rd, Aberdeen, Hong Kong, 00000, Peoples R China (see also Heart Disorders and Diseases - Atrial Fibrillation).
The news editors report that additional information may be obtained by contacting M.K. Fong, Princess Margaret Hospital, Dept. of Med & Geriatr, Laichikok, Hong Kong, People's Republic of China. Additional authors for this research include B. Sheng, Y.P. Chu, W.T. Wong, P.P.K. Lau, H.Y. Wong and K.K. Lau.
Keywords for this news article include: Hong Kong, People's Republic of China, Asia, Coumarin and Indandione Derivative, Heart Disorders and Diseases, Coumarins and Indandiones, Coagulation Modifiers, Drugs and Therapies, Atrial Fibrillation, Cardiac Arrhythmias, Warfarin Therapy, Anticoagulants, Heart Disease, Rodenticide, Princess Margaret Hospital.
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