Findings from Kaohsiung Chang Gung Memorial Hospital Provides New Data about C Reactive Protein (C-reactive protein variability is associated with vascular access outcome in hemodialysis patients)
By a News Reporter-Staff News Editor at Science Letter Fresh data on C Reactive Protein are presented in a new report. According to news originating from Kaohsiung, Taiwan, by NewsRx correspondents, research stated, "Hemodialysis (HD) vascular access failure is one of the most important causes of morbidity and contributes to the cost of dialysis care. There is paucity of data evaluating long-term monitoring of C-reactive protein (CRP) on outcome of HD vascular access."
Our news journalists obtained a quote from the research from Kaohsiung Chang Gung Memorial Hospital, "We conducted a retrospective study to investigate whether variability of serum CRP level was associated with vascular access failure rate over a 7-year period. A total of 318 HD patients were included. Their demographic data, co-morbidities and biochemical data were reviewed and collected. Serum high-sensitivity CRP (hs-CRP) level was measured every 6?months. Patients were divided into three groups according to their serial hs-CRP levels. Patients with their hs-CRP below 2?mg/L were defined as low group (n=65, 20.4%) and those with higher than 4?mg/L were defined as high (n=39, 12.3%). The rest were classified as fluctuated hs-CRP group (n=214, 67.3%). Treatment of vascular access failure includes angioplasty and access re-creation. Their body mass index, indicators of dialysis adequacy and serum albumin and hs-CRP levels differed significantly among three groups. The annual vascular access failure rate was significantly higher in fluctuated hs-CRP group than in high hs-CRP group (0.41 vs 0.36, p=.037). Serum albumin was a significant associate of vascular access failure. Kaplan-Meier survival analysis indicated patients with high or fluctuated hs-CRP had shorter free interval of vascular access failure than low hs-CRP group."
According to the news editors, the research concluded: "HD patients with fluctuated hs-CRP levels were associated with increased vascular access failure."
For more information on this research see: C-reactive protein variability is associated with vascular access outcome in hemodialysis patients. Journal of Clinical Laboratory Analysis, 2017;():. (Wiley-Blackwell - www.wiley.com/; Journal of Clinical Laboratory Analysis - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1098-2825)
The news correspondents report that additional information may be obtained from W.H. Kuo, Division of Nephrology, Dept. of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan. Additional authors for this research include Y.T. Lee, H.Y. Ng, C.Y. Wang, C.H. Wu and C.T Lee (see also C Reactive Protein).
Keywords for this news article include: Asia, Taiwan, Albumins, Kaohsiung, Immunology, Proteomics, Hemodialysis, Immunoproteins, Renal Dialysis, C Reactive Protein, Acute Phase Proteins.
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