Investigators at Mahidol University Describe Findings in Liver Cancer (Development of self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy)
By a News Reporter-Staff News Editor at Drug Week Investigators publish new report on Oncology - Liver Cancer. According to news originating from Nakorn Panom, Thailand, by NewsRx correspondents, research stated, "The objective of this work was to develop self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy and studied the release profiles of doxorubicin (Dox) from different depot formulations. Tri-block copolymers of poly(e-caprolactone), poly(D, L-lactide) and poly(ethylene glycol) named PLECs were successfully used as a biodegradable material to encapsulate Dox as the injectable local drug delivery system."
Our news journalists obtained a quote from the research from Mahidol University, "Depot formation and encapsulation efficiency of these depots were evaluated. Results show that depots could be formed and encapsulate Dox with high drug loading content. For the release study, drug loading content (10, 15 and 20% w/w) and polymer concentration (25, 30, and 35% w/v) were varied. It could be observed that the burst release occurred within 1-2 days and this burst release could be reduced by physical mixing of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) into the depot system. The degradation at the surface and cross-section of the depots were examined by Scanning Electron Microscope (SEM). In addition, cytotoxicity of Dox-loaded depots and blank depots were tested against human liver cancer cell lines (HepG2). Dox released from depots significantly exhibited potent cytotoxic effect against HepG2 cell line compared to that of blank depots."
According to the news editors, the research concluded: "Results from this study reveals an important insight in the development of injectable drug delivery system for liver cancer chemotherapy."
For more information on this research see: Development of self-forming doxorubicin-loaded polymeric depots as an injectable drug delivery system for liver cancer chemotherapy. Journal of Materials Science-Materials in Medicine, 2017;28(7):22-34. Journal of Materials Science-Materials in Medicine can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands (see also Oncology - Liver Cancer).
The news correspondents report that additional information may be obtained from N. Nasongkla, Mahidol University, Fac Engn, Dept. of Biomed Engn, Nakhon Pathom 73170, Thailand.
Keywords for this news article include: Nakorn Panom, Thailand, Asia, Antibiotics - Antineoplastics, Drug Delivery Systems, Drugs and Therapies, Doxorubicin Therapy, Pharmaceuticals, Chemotherapy, Liver Cancer, Oncology, Mahidol University.
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