Study Findings from Shenyang Pharmaceutical University Provide New Insights into Transdermal Delivery (Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous ...)
By a News Reporter-Staff News Editor at Biotech Week Research findings on Drugs and Therapies - Transdermal Delivery are discussed in a new report. According to news reporting originating from Liaoning, People's Republic of China, by NewsRx correspondents, research stated, "In this paper, based on the optimized formulation of olanzapine (OLN) transdermal patch, the role of sorbitan monooleate (SP) in OLN release and percutaneous absorption processes was probed in vitro and in vivo. Rheological test, DSC, FT-IR and molecular modeling were conducted to elucidate the effect of SP on the release process of OLN from transdermal patch."
Our news editors obtained a quote from the research from Shenyang Pharmaceutical University, "Additionally, the action of SP on the percutaneous absorption process was probed using tape stripping transdermal experiment, confocal laser scanning microscopy (CLSM), ATR-FTIR and molecular docking. The results showed that the hydrogen bonding interaction between OLN and pressure sensitive adhesive (PSA) was weakened by SP, which resulted in a decrease in the cohesive interaction between polymer chains and an increase in the formation of free volume of PSA, thus, the release of OLN from patch was promoted. Meanwhile, the O-II groups of SP interacted with the polar head groups of the ceramides, which increased the fluidity of the skin lipids, thereby improved the ability of OLN percutaneous absorption. In summary, this study demonstrated that not only the release but also the percutaneous absorption processes were promoted by SP."
According to the news editors, the research concluded: "This study provided comprehensive molecular level understanding on the effect of penetration enhancer on transdermal patch and strategies for rationally selection of chemical enhancer for transdermal drug delivery systems."
For more information on this research see: Mechanistic insights of the enhancement effect of sorbitan monooleate on olanzapine transdermal patch both in release and percutaneous absorption processes. European Journal of Pharmaceutical Sciences, 2017;107():138-147. European Journal of Pharmaceutical Sciences can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; European Journal of Pharmaceutical Sciences - www.journals.elsevier.com/european-journal-of-pharmaceutical-sciences/)
The news editors report that additional information may be obtained by contacting L. Fang, Shenyang Pharmaceutical University, Dept. of Pharmaceut Sci, Shenyang 110016, Liaoning, People's Republic of China. Additional authors for this research include P. Quan, X.C. Wan, C. Liu, X.C. Liu and N. Li (see also Drugs and Therapies - Transdermal Delivery).
Keywords for this news article include: Liaoning, People's Republic of China, Asia, Psychotherapeutic Agents, Atypical Antipsychotics, Transdermal Delivery, Drugs and Therapies, Olanzapine Therapy, Transdermal Patch, Medical Devices, Pharmaceuticals, Biotechnology, Shenyang Pharmaceutical University.
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