New Transdermal Delivery Findings from University of Sunderland Outlined [Effect of Drug LoadingMethod and Drug Physicochemical Properties on theMaterial and Drug Release Properties of Poly (Ethylene Oxide) Hydrogels for Transdermal Delivery]
By a News Reporter-Staff News Editor at Biotech Week Current study results on Drugs and Therapies - Transdermal Delivery have been published. According to news reporting from Sunderland, United Kingdom, by NewsRx journalists, research stated, "Novel poly (ethylene oxide) (PEO) hydrogel films were synthesized via UV cross-linking with pentaerythritol tetra-acrylate (PETRA) as cross-linking agent. The purpose of this work was to develop a novel hydrogel film suitable for passive transdermal drug delivery via skin application."
The news correspondents obtained a quote from the research from the University of Sunderland, "Hydrogels were loaded with model drugs (lidocaine hydrochloride (LID), diclofenac sodium (DIC) and ibuprofen (IBU)) via post-loading and in situ loading methods. The effect of loading method and drug physicochemical properties on the material and drug release properties of medicated film samples were characterized using scanning electron microscopy (SEM), swelling studies, differential scanning calorimetry (DSC), fourier transform infrared spectroscopy (FT-IR), tensile testing, rheometry, and drug release studies. In situ loaded films showed better drug entrapment within the hydrogel network and also better polymer crystallinity. High drug release was observed from all studied formulations. In situ loaded LID had a plasticizing effect on PEO hydrogel, and films showed excellent mechanical properties and prolonged drug release."
According to the news reporters, the research concluded: "The drug release mechanism for the majority of medicated PEO hydrogel formulations was determined as both drug diffusion and polymer chain relaxation, which is highly desirable for controlled release formulations."
For more information on this research see: Effect of Drug LoadingMethod and Drug Physicochemical Properties on theMaterial and Drug Release Properties of Poly (Ethylene Oxide) Hydrogels for Transdermal Delivery. Polymers, 2017;9(7):531-559. Polymers can be contacted at: Mdpi Ag, St Alban-Anlage 66, Ch-4052 Basel, Switzerland. (Wiley-Blackwell - www.wiley.com/; Polymers - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1099-1581)
Our news journalists report that additional information may be obtained by contacting R.S.H. Wong, University of Sunderland, Sch Pharm & Pharmaceut Sci, Fac Hlth Sci & Wellbeing, Sunderland SR1 3SD, Durham, United Kingdom (see also Drugs and Therapies - Transdermal Delivery).
Keywords for this news article include: Sunderland, United Kingdom, Europe, Polyethylene Glycols, Transdermal Delivery, Drugs and Therapies, Organic Chemicals, Drug Development, Epoxy Compounds, Ethylene Oxide, Biotechnology, Ethylenes, Alcohols, Hydrogel, Alkenes, University of Sunderland.
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