Data on Transdermal Delivery Reported by Researchers at University of Sunderland (Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic ...)
By a News Reporter-Staff News Editor at Biotech Week Current study results on Drugs and Therapies - Transdermal Delivery have been published. According to news reporting from Sunderland, United Kingdom, by NewsRx journalists, research stated, "Microreservoir-type transdermal drug delivery systems (MTDDS) can prevent drug crystallization; however, no current predictive model considers the impact of drug load and hydration on their physical stability. We investigated MTDDS films containing polyvinylpyrrolidone (PVP) as polymeric drug stabilizer in lipophilic pressure-sensitive adhesive (silicone)."
The news correspondents obtained a quote from the research from the University of Sunderland, "Medicated and unmedicated silicone films with different molar N-vinylpyrrolidone: drug ratios were prepared and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, scanning electron microscopy, microscopy, dynamic vapor sorption (DVS), and stability testing for 4 months at different storage conditions. Homogeneously distributed drug-PVP associates were observed when nonaqueous emulsions, containing drug-PVP (inner phase) and silicone adhesive (outer phase), were dried to films. DVS data were essential to predict physical stability at different humidities. A predictive thermodynamic model was developed based on drug-polymer hydrogen-bonding interactions, using the Hoffman equation, to estimate the drug-PVP ratio needed to obtain stable MTDDS and to evaluate the impact of humidity on their physical stability. This new approach considers the impact of polymorphism on drug solubility by using easily accessible experimental data (T-m and DVS) and avoids uncertainties associated with the solubility parameter approach."
According to the news reporters, the research concluded: "A good fit of predicted and experimental data was observed."
For more information on this research see: Development of a Predictive Model for the Stabilizer Concentration Estimation in Microreservoir Transdermal Drug Delivery Systems Using Lipophilic Pressure-Sensitive Adhesives as Matrix/Carrier. Journal of Pharmaceutical Sciences, 2017;106(5):1371-1383. Journal of Pharmaceutical Sciences can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)
Our news journalists report that additional information may be obtained by contacting K. Dodou, University of Sunderland, Sunderland Pharm Sch, Fac Appl Sci, Sunderland SR1 3SD, Tyne & Wear, United Kingdom. Additional authors for this research include H.M. Wolff, M. Ashton, M. Schubert and C. Chenevas-Paule (see also Drugs and Therapies - Transdermal Delivery).
Keywords for this news article include: Sunderland, United Kingdom, Europe, Drug Delivery Systems, Transdermal Delivery, Drugs and Therapies, Biotechnology, University of Sunderland.
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