Findings from University of Westminster Provides New Data on Drug Delivery Systems (Core-Sheath Nanofibers as Drug Delivery System for Thermoresponsive Controlled Release)
By a News Reporter-Staff News Editor at Biotech Week A new study on Drugs and Therapies - Drug Delivery Systems is now available. According to news reporting out of London, United Kingdom, by NewsRx editors, research stated, "In this work, a smart drug delivery system of core-sheath nanofiber is reported. The core-sheath nanofibers were prepared with thermoresponsive poly-(N-isopropylacrylamide) (as core) and hydrophobic ethyl cellulose (as sheath) by coaxial electrospinning."
Our news journalists obtained a quote from the research from the University of Westminster, "Analogous medicated fibers were prepared by loading with a model drug ketoprofen (KET). The fibers were cylindrical without phase separation and have visible core-sheath structure as shown by scanning and transmission electron microscopy. X-ray diffraction patterns demonstrated the drug with the amorphous physical form was present in the fiber matrix. Fourier transform infrared spectroscopy analysis was conducted, finding that there were significant intermolecular interactions between KET and the polymers. Water contact angle measurements proved that the core-sheath fibers from hydrophilic transformed into hydrophobic when the temperature reached the lower critical solution temperature. In vitro drug-release study of nanofibers with KET displayed that the coaxial nanofibers were able to synergistically combine the characteristics of the 2 polymers producing a temperature-sensitive drug delivery system with sustained-release properties. In addition, they were established to be nontoxic and suitable for cell growth."
According to the news editors, the research concluded: "These findings show that the core-sheath nanofiber is a potential candidate for controlling drug delivery system."
For more information on this research see: Core-Sheath Nanofibers as Drug Delivery System for Thermoresponsive Controlled Release. Journal of Pharmaceutical Sciences, 2017;106(5):1258-1265. Journal of Pharmaceutical Sciences can be contacted at: Wiley, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Pharmaceutical Sciences - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1520-6017)
Our news journalists report that additional information may be obtained by contacting S.W.A. Bligh, Univ Westminster, Fac Sci & Technol, Dept. of Life Sci, London W1W 6UW, United Kingdom. Additional authors for this research include Q.X. Pan, Y. Lv, H.Y. Li, H.L. Wu, Q.Q. Sang and L.M. Zhu (see also Drugs and Therapies - Drug Delivery Systems).
Keywords for this news article include: London, United Kingdom, Europe, Drug Delivery Systems, Emerging Technologies, Drugs and Therapies, Controlled Release, Nanotechnology, Nanofiber, University of Westminster.
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