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 The leading web portal for pharmacy resources, news, education and careers November 18, 2017
Pharmacy Choice - Pharmaceutical News - Research Results from St. Jude Children's Research Hospital Update Knowledge of Solid Cancer (Orthotopic patient-derived xenografts of paediatric... - November 18, 2017

Pharmacy News Article

 9/13/17 - Research Results from St. Jude Children's Research Hospital Update Knowledge of Solid Cancer (Orthotopic patient-derived xenografts of paediatric...

Research Results from St. Jude Children's Research Hospital Update Knowledge of Solid Cancer (Orthotopic patient-derived xenografts of paediatric solid tumours)

By a News Reporter-Staff News Editor at Biotech Week Research findings on Oncology - Solid Cancer are discussed in a new report. According to news originating from Memphis, Tennessee, by NewsRx correspondents, research stated, "Paediatric solid tumours arise from endodermal, ectodermal, or mesodermal lineages. Although the overall survival of children with solid tumours is 75%, that of children with recurrent disease is below 30%."

Our news journalists obtained a quote from the research from St. Jude Children's Research Hospital, "To capture the complexity and diversity of paediatric solid tumours and establish new models of recurrent disease, here we develop a protocol to produce orthotopic patient-derived xenografts at diagnosis, recurrence, and autopsy. Tumour specimens were received from 168 patients, and 67 orthotopic patient-derived xenografts were established for 12 types of cancer. The origins of the patient-derived xenograft tumours were reflected in their gene-expression profiles and epigenomes. Genomic profiling of the tumours, including detailed clonal analysis, was performed to determine whether the clonal population in the xenograft recapitulated the patient's tumour."

According to the news editors, the research concluded: "We identified several drug vulnerabilities and showed that the combination of a WEE1 inhibitor (AZD1775), irinotecan, and vincristine can lead to complete response in multiple rhabdomyosarcoma orthotopic patient-derived xenografts tumours in vivo."

For more information on this research see: Orthotopic patient-derived xenografts of paediatric solid tumours. Nature, 2017;():. (Nature Publishing Group - www.nature.com/; Nature - www.nature.com/nature/)

The news correspondents report that additional information may be obtained from E. Stewart, Dept. of Oncology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, United States. Additional authors for this research include S.M. Federico, X. Chen, A.A. Shelat, C. Bradley, B. Gordon, A. Karlstrom, N.R. Twarog, M.R. Clay, A. Bahrami, B.B. Freeman, B. Xu, X. Zhou, J. Wu, V. Honnell, M. Ocarz, K. Blankenship, J. Dapper, E.R. Mardis and W (see also Oncology - Solid Cancer).

Keywords for this news article include: Biotechnology, Memphis, Genetics, Oncology, Tennessee, Pediatrics, Xenografts, Solid Cancer, United States, Xenotransplantion, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2017, NewsRx LLC



(c) 2017 NewsRx LLC

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